Association Between Hidradenitis Suppurativa and Spondyloarthritis

Hidradenitis Suppurativa Clinical Trial

— VESPA  

Official title:

Association Between Hidradenitis Suppurativa and Spondyloarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03668925
• Other study ID #: PJ12076
• Status: Completed
• Phase: N/A
• Start date: May 1, 2013
• Est. completion date: September 1, 2015

Study information

• Verified date: August 2018
• Source: CHU de Reims
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hidradenitis suppurativa is a chronic dermatosis, characterized by an inflammation of the follicular epithelium in the apocrine glands.

The hypothesis of a link between hidradenitis suppurativa and inflammatory rheumatism has been widely considered, with evidence in support of this theory accumulating from several case reports and small series. The most frequently cited rheumatismal disease thought to be associated with Hidradenitis suppurativa is spondyloarthritis.

Taken together, these data suggest that there may a link between hidradenitis suppurativa and spondyloarthritis, but literature data are sparse, and to date, no study has investigated or demonstrated such a relation. Indeed, existing studies to date were observational, descriptive, and retrospective, and did not use modern diagnostic approaches for documenting spondyloarthritis, such as magnetic resonance imaging (MRI) or the recent classification of spondyloarthritis.

Description:

The aim of the study was to test the hypothesis that the risk of spondyloarthritis is increased in patients with hidradenitis suppurativa.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 1, 2015
• Est. primary completion date: April 1, 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• for case: patients with diagnosis of hidrosadenitis suppurativa in the Department of Dermatology of the University Hospital of Reims, regardless of the stage of severity and duration of their disease

• for control: patients without diagnosis of hidrosadenitis suppurativa matched to cases for age (±5 years) and sex

• for case and control: have accepted to take part in the research

Exclusion Criteria:

• for case and control: age <18 years old

Related Conditions & MeSH terms

• Hidradenitis
• Hidradenitis Suppurativa
• Spondylarthritis

Intervention

Radiation:
• magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement
magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement

Locations

Country	Name	City	State
France	Damien JOLLY	Reims

Sponsors (1)

Lead Sponsor	Collaborator
CHU de Reims

Country where clinical trial is conducted

France, 

References & Publications (1)

Fauconier M, Reguiai Z, Barbe C, Colosio A, Eschard JP, Salmon JH, Direz G. Association between hidradenitis suppurativa and spondyloarthritis. Joint Bone Spine. 2017 Sep 28. pii: S1297-319X(17)30164-1. doi: 10.1016/j.jbspin.2017.09.005. [Epub ahead of print] — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	spondyloarthritis	spondyloarthritis was diagnosed by a rheumatologist using the Assessment of SpondyloArthritis international Society (ASAS) criteria	Day 0