Autonomic Changes of Cardiomyocytes Repolarisation Clinical Trial
Official title:
Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes
The aim of this study is to evaluate influence of atorvastin on the repolarisation phase of
cardiomyocytes. If there is any, it could be a part of positive "non-lipid" effect of
statins in therapy of ischaemic heart disease.
Study hypothesis: atorvastin will decrease heterogeneity of repolarisation of cardiomyocytes
in comparison with placebo
The group will consist of 40 healthy volunteers. The study will be mono-centric. The repolarisation phase of cardiomyocytes will be evaluated using long - term 12-lead digital ECG monitoring. There will be 3 single ECG recordings - randomly after 20 mg of atorvastin, 80 mg of atorvastatin and placebo, respectively. ;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science