Herpes Zoster Clinical Trial
Official title:
Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes
The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
| Status | Not yet recruiting |
| Enrollment | 600 |
| Est. completion date | December 2026 |
| Est. primary completion date | May 2026 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: 1. Age more than 18 years old 2. Diagnosed as herpes zoster neuralgia 3. Signing informed consent Exclusion Criteria: 1. Unable to complete the scale assessment 2. History of mental illness |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Huazhong University of Science and Technology |
Du J, Sun G, Ma H, Xiang P, Guo Y, Deng Y, Li S, Li X. Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study. Dermatology. 2021;237(6):891-895. doi: 10.1159/000512190. Epub 2020 Dec 16. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | HADS score | Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression. | during hospital stay, average of 1 week | |
| Secondary | Interleukin (IL)-1ß plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-1ß (pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | IL-2 receptor plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-2 (u/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | IL-6 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-6 (pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | IL-8 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-8 (pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | IL-10 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-10 (pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | Interferon(INF)-a plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines INF-a (pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | Brain-derived neurotrophic factor (BDNF) plasma level | Blood sample will be obtained from enrolled patients and the plasma level of BDNF(pg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | C-reactive protein (CRP) plasma level | Blood sample will be obtained from enrolled patients and the plasma level of CRP(mg/ml)will be tested. | during hospital stay, average of 1 week | |
| Secondary | Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging | Functional brain magnetic resonance imaging will be performed in patients with anxiety or depression, and area under curve (AUC) of topological metrics including Eglob,Eloc,Cp,Lp,?,? and s will be calculated and analyzed. | during hospital stay, average of 1 week |
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