Atopic Dermatitis Clinical Trial
Official title:
Investigation of Reduced Interferon Responses in Peripheral Blood Mononuclear Cells of Participants With Atopic Dermatitis and a History of Eczema Herpeticum (ADRN-01)
Atopic dermatitis (AD) is a chronic skin disorder characterized by recurrent viral skin infections. A small subset of patients with AD suffer from disseminated viral infections, e.g., eczema herpeticum (ADEH+), after herpes simplex infection (HSV) or eczema vaccinatum (EV) after smallpox vaccination. Interferon gamma (IFNγ) plays a critical role in the innate and acquired immune responses by activating macrophages, enhancing natural killer cell activation, and promoting T cell differentiation, as well as regulating B cell isotype switching to immunoglobulin (Ig) G2a. Recent studies have demonstrated that IFNγ generation was significantly decreased after stimulation with HSV ex vivo. The purpose of this study is to determine if deficient IFNγ induction leads to susceptibility to HSV infection in ADEH+ patients.
The investigators hypothesize that defective IFNγ responses in peripheral blood mononuclear
cells (PBMCs) from ADEH+ patients results from aberrant pattern recognition receptors (PRR)
signaling in antigen-presenting cells (APCs) resulting in low level production of IL-12, an
essential cytokine for IFNγ generation. This study will compare results from 40 ADEH+, 40
ADEH-, and 40 non-atopic participants.
Study procedures will typically be completed in one visit; however, participants may be
asked to return for additional unscheduled visit(s) occurring as frequently as every 3
months for the duration of the study to provide an additional blood sample for further
characterization of immune mechanisms leading to reduced IFNγ responses in ADEH+.
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