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Heroin Dependence clinical trials

View clinical trials related to Heroin Dependence.

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NCT ID: NCT00471042 Completed - Clinical trials for Opioid-Related Disorders

Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care

Start date: June 2006
Phase:
Study type: Observational

The purpose of this treatment research study is to assess the effectiveness of buprenorphine maintenance treatment for opioid dependence delivered in a primary care clinic setting. This study will determine whether buprenorphine treatment in primary care is effective in reducing cravings, reducing illicit opioid use, reducing addiction severity, and retaining patients in primary care treatment for opioid dependence.

NCT ID: NCT00429767 Completed - Clinical trials for Opioid-Related Disorders

Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals

Start date: January 2007
Phase: Phase 1
Study type: Observational

The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases self-administration of cocaine alone or combined with hydromorphone (HYD). Secondary aims are to determine whether SR-AMP attenuates the subjective and physiological effects of cocaine during drug sampling periods prior to choice opportunities.

NCT ID: NCT00378079 Completed - Heroin Addiction Clinical Trials

Methadone Maintenance for Prisoners

MMP
Start date: September 2003
Phase: Phase 3
Study type: Interventional

This five-year study examines the benefits of methadone maintenance treatment initiated in prison and continued in the community to male offenders who were previously, but not currently, heroin-dependent. It is anticipated that such prisoners will have more favorable outcomes in the year following release with regard to drug abuse, crime, and HIV risk behavior than either prisoners who receive counseling only or begin initiation of methadone maintenance in the community

NCT ID: NCT00332228 Completed - Opiate Dependence Clinical Trials

Behavioral Naltrexone Therapy: A Novel Treatment for Heroin Dependence

Start date: June 2002
Phase: Phase 2
Study type: Interventional

The overall goal of this research project is to test the efficacy of a newly developed therapy, Behavioral Naltrexone Therapy (BNT), to enhance the success of naltrexone maintenance and long-term abstinence for individuals with heroin dependence. This study includes free detox and outpatient treatment for opioid dependence that includes medication and a behavioral intervention.

NCT ID: NCT00326235 Completed - Heroin Dependence Clinical Trials

Effects of Buspirone in Opiate Withdrawal

Start date: January 2002
Phase: Phase 4
Study type: Interventional

Dependence on heroin is a major public health problem because of its association with criminality, law enforcement costs and healthcare costs. Managed withdrawal is a required first step for a long term drug-free treatment of heroin addicts. Methadone and clonidine have been the mainstay of treatment for the relief of heroin withdrawal symptoms but both have limitations. The purpose of this study was to evaluate the efficacy of buspirone in the alleviation of the withdrawal symptoms experienced by heroin addicts when they stop using heroin. Buspirone is a non opiate drug with no abuse potential, no sedating effects and no withdrawal symptoms.

NCT ID: NCT00318760 Completed - Cocaine Abuse Clinical Trials

Effect of Clonidine on Responses to Imagery Scripts

Start date: June 14, 2005
Phase: Phase 1
Study type: Interventional

Background: - Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats. However, it does not seem to block cue-induced relapse in rats. Researchers are interested in studying whether clonidine shows the same pattern of effects on stress- and cue-induced cravings for heroin or cocaine in humans. Objectives: - To compare the ability of clonidine to reduce stress- and cue-induced cocaine and heroin craving in drug abusers. Eligibility: - Individuals between 18 and 55 years of age who are current cocaine or heroin users. Design: - This study will consist of two visits: a screening visit to determine eligibility and an experimental/script session. - Before the script session, participants will provide urine and breath samples for testing. Participants will complete questionnaires to measure their current drug craving and days since last use of cocaine or heroin. - At the start of the script session, participants will receive a dose of clonidine or placebo as directed by the study researchers. Three hours after dosing, participants will be read four scripts (two neutral, one stress-inducing, and one drug-cue-related) with breaks in between each script. After each script, participants will respond to questions about levels of stress and craving. - Participants will provide saliva samples immediately before and during the script readings, and will also be measured for skin response to the scripts.

NCT ID: NCT00310934 Completed - Heroin Dependence Clinical Trials

A Stepwise Strategy Utilizing Buprenorphine and Methadone

Start date: August 2005
Phase: Phase 4
Study type: Interventional

The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy, where patients are offered buprenorphine as first line treatment, allowed dose adjustments as needed, and switched to methadone if the maximal dose of buprenorphine is insufficient.

NCT ID: NCT00279110 Completed - HIV Infections Clinical Trials

Directly Administered HIV Therapy in Methadone Clinics

Start date: April 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether providing directly administered antiretroviral therapy to HIV-infected who receive methadone therapy leads to better treatment outcomes than if they take HIV medications on their own.

NCT ID: NCT00249574 Completed - Hepatitis C Clinical Trials

Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1

Start date: June 2003
Phase: N/A
Study type: Interventional

The purpose of this study is to see whether street-recruited heroin users can be successfully treated for hepatitis C after stabilizing them on buprenorphine.

NCT ID: NCT00249470 Completed - Clinical trials for Opioid-Related Disorders

The Therapeutic Workplace Initiation Study

Start date: April 2003
Phase: N/A
Study type: Interventional

The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients who use cocaine consistently during methadone treatment. All subjects initially will be invited to attend the Therapeutic Workplace for an initial period, but abstinence will not be required to work during that time. During this initial period, vouchers will be contingent only on workplace attendance and performance on the training programs. Subjects (n=70) who attend the workplace consistently during the first 4 weeks of treatment, but who continue to use cocaine will be randomly assigned to a Work Only or an Abstinence Plus Work group. Subjects in the Work Only group will continue to be able to work independent of their urinalysis results. However, subjects in the Abstinence Plus Work group will be required to provide urine samples that show evidence of recent cocaine abstinence. Subjects in both groups will be invited to stay in the workplace for 6 months. We expect the subjects in the Abstinence and Work group will achieve higher rates of abstinence than the subjects in the Work Only group. This result would show that the abstinence reinforcement contingency (i.e., the requirement to provide cocaine-free urine samples to work and earn vouchers) is important in the initiation of abstinence in the study population.