Hernia Clinical Trial - Characterization of Explanted Hernia Meshes From

Status Terminated

Clinical Trial Summary

Clinical Trial Description

This study will collect a large amount of hernia mesh explants and study the changes that occur in the materials in vivo to use the information to help design new mesh made from novel materials. We will have evidence that our current options are not only inadequate but can lead to complications. One of our main goals is to convince our colleagues to change their surgical practice by publishing and educating them with this data. The objectives of this study are to establish the largest collection of explanted mesh materials in the country; demonstrate by common testing utilized by materials engineers, that in vivo exposure of mesh to the oxidants produced by phagocytosis may lead to chain scission, production of free radicals, and overall degradation of the material both physically and chemically; test mesh materials for a decrease in compliance, which would account for a tendency of mesh to stiffen while in the body reducing abdominal mobility and leading to chronic pain; characterize the histologic reaction of tissues to mesh; and utilize de-identified patient demographics to identify possible clinical characteristics which affect mesh degradation. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Hernia
Pathological Conditions, Signs and Symptoms
Signs and Symptoms

Clinical Trial Details

NCT number	NCT00484887
Study type	Observational
Source	University of Missouri-Columbia
Contact
Status	Terminated
Phase	N/A
Start date	April 2007
Completion date	February 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01629485` - Part vs Whole Task Mastery Training for Laparoscopic Hernia Repair	N/A
Completed	`NCT01205399` - A Retrospective Study With Prospective Follow-Up of Complex Ventral Hernia Repair Utilizing the AlloMax Surgical Graft	N/A
Terminated	`NCT01305486` - A Study of Complex Ventral Hernia Repair Utilizing the XenMatrix™ Surgical Graft With Component Separation	N/A
Completed	`NCT01141335` - Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair	Phase 4
Completed	`NCT00905320` - Hernia Repair With or Without Sutures	N/A
Completed	`NCT00617357` - Repair of Infected or Contaminated Hernias	N/A
Completed	`NCT00535990` - Minimally Invasive Surgery (MIS) Database for the Purpose of Research
Withdrawn	`NCT00138957` - Study of a New Laparoscopic Technique for Parastomal Hernia Repair With Mesh	N/A
Completed	`NCT06034652` - T-GENVIH-003 LTFU (Long Term Follow Up) Study
Completed	`NCT06389331` - Study on Effects of Defect Closure in Laparoscopic Repair of Direct Inguinal Hernia
Completed	`NCT04119466` - Stabilizing Training in Degenerative Disc Disease	N/A
Completed	`NCT00622583` - International Hernia Mesh Registry
Completed	`NCT04137172` - Short Term Outcomes of Laparoscopic Intraperitoneal Onlay Mesh With Facial Repair(IPOM-plus) for Ventral Hernia.	N/A
Completed	`NCT01132209` - Suture Techniques to Reduce the Incidence of The inCisional Hernia	N/A
Completed	`NCT00032448` - Does Tension-Free Herniorrhaphy or Laparoscopic Herniorrhaphy Achieve Equal or Better Recurrence Rates and Lower Costs While Achieving Equivalent Outcomes for Hernia Patients?	Phase 3
Not yet recruiting	`NCT05061589` - Incidence and Risk Factors of Parastomal Hernia in Patients With Permanent Colostomy in China
Active, not recruiting	`NCT02439060` - PUBMIC (Prophylactic Use of Biologic Mesh in Ileal Conduit)	N/A
Completed	`NCT01727388` - Informativeness to Digital Rectal Examination	Phase 3
Completed	`NCT02238964` - Reinforcement of Closure of Stoma Site	Phase 2/Phase 3
Completed	`NCT01997619` - Biological Mesh Repair of Complex Hernias in High Risk Patients	N/A

Characterization of Explanted Hernia Meshes From Human Subjects: A Multi-Center, Prospective Study

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms