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Hereditary Breast Cancer clinical trials

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NCT ID: NCT04197856 Enrolling by invitation - Lynch Syndrome Clinical Trials

Direct Information to At-risk Relatives

DIRECT
Start date: February 6, 2020
Phase: N/A
Study type: Interventional

This study evaluates if uptake of genetic counselling in high-risk families is increased when patients at cancer genetics clinics are being offered healthcare-assisted disclosure to at-risk relatives compared to current standard care (with family-mediated disclosure). Patients/families who have undergone a cancer genetic investigation will be invited to participate in the study. All participants will receive standard care. Half of them will in addition be offered a healthcare-assisted disclosure with the service of direct letters to identified at-risk relatives distributed by the healthcare provider. After a year we will compare the proportion of at-risk relatives who have contacted a cancer genetic clinics in each study arm.

NCT ID: NCT03959267 Completed - Breast Cancer Clinical Trials

Testing a Culturally Adapted Telephone Genetic Counseling Intervention

Start date: July 7, 2017
Phase: N/A
Study type: Interventional

Participating in genetic cancer risk assessments (GCRA) for hereditary breast and ovarian cancer (HBOC) can inform treatment and risk management decisions and improve breast cancer outcomes. However, Latina women underuse GCRA services, which may increase breast cancer disparities. This study will adapt and test the impact of a Culturally Adapted Telephone Genetic Counseling Intervention to enhance the use and quality of genetic counseling services for underserved Latina women at-risk of hereditary breast and ovarian cancer

NCT ID: NCT03495544 Recruiting - Clinical trials for Hereditary Breast Cancer

Study Estimating Association Between Germline Mutations and PD-L1 Expression in Breast Cancer

Start date: January 1, 2018
Phase:
Study type: Observational

This is a multicentre, non-interventional, prospective study to be carried out in representative oncology departments / institutions in order to determine the association between the presence of germline DNA-repair genes mutations and PD-L1 expression level in tumour and immune cells in breast cancer. No additional procedures besides those already used in the routine clinical practice will be applied to the patients.

NCT ID: NCT02557776 Completed - Clinical trials for Hereditary Breast Cancer

Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast Cancer

BRCAsearch
Start date: February 2015
Phase: N/A
Study type: Interventional

The overall purpose of the study is to evaluate a method for offering mutation analysis of BRCA1 and BRCA2 to all patients with newly diagnosed breast cancer, regardless of age at diagnosis and family history. Information about the study as well as pre-test genetic counseling will primarily be given in a written way. In addition to that, if a study participant wishes to, she can also receive pre-test telephone genetic counseling.