HER2-positive Breast Cancer Clinical Trial
Official title:
Spatial Transcriptomic Approach for Revealing the Resistance Mechanism of Trastuzumab Deruxtexan in HER2 Positive Breast Cancer Patients.
This study is the spatial transcriptomic approach for revealing the resistance mechanism of trastuzumab deruxtexan in HER2 positive breast cancer patients.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 31, 2027 |
Est. primary completion date | January 15, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - HER2 positive breast cancer - Stage IV disease - Treated with T-Dxd - Available FFPE samples Exclusion Criteria: - TNBC breast cancer - Hormone receptor positive breast cancer - Non-available FFPE samples - Treated except T-Dxd |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Ji-Yeon Kim | Seoul |
Lead Sponsor | Collaborator |
---|---|
Samsung Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Spatial transcriptomic analysis | Protein expression and relationship protein-protein in HER2 positive breast cancer tumor cells and tumor microenvironment. | Before chemotherapy, curative surgery |
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