The Resistance Mechanism of Trastuzumab Deruxtexan in HER2 Positive Breast

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04095390` - A Phase Ⅱ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer	Phase 2
Recruiting	`NCT04578106` - Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy	Phase 2
Terminated	`NCT01912963` - Phase II Study of Eribulin Mesylate, Trastuzumab, and Pertuzumab in Women With Metastatic, Unresectable Locally Advanced, or Locally Recurrent HER2-Positive Breast Cancer	Phase 2
Completed	`NCT01855828` - Phase 2 Trial of Pertuzumab and Trastuzumab With Weekly Paclitaxel and Chemotherapy for HER2 Positive Breast Cancer	Phase 2
Terminated	`NCT01705340` - Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery	Phase 1
Recruiting	`NCT04094896` - TCHP Versus EC -THP as Neoadjuvant Treatment for HER2-Positive Breast Cancer	Phase 2
Recruiting	`NCT06087120` - Investigate the Prognostic and Predictive Value of ctDNA During Neoadjuvant Chemotherapy for Breast Cancer.
Recruiting	`NCT04899908` - Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases	Phase 2
Recruiting	`NCT05346861` - Pyrotinib Rechallenge in Her2-positive Metastatic Breast Cancer Pretreated With Pyrotinib and Trastuzumab	Phase 3
Completed	`NCT03330561` - PRS-343 in HER2-Positive Solid Tumors	Phase 1
Recruiting	`NCT04997798` - Dalpiciclib in Combination With Exemestane and Trastuzumab Plus Pyrotinib in Early Triple Positive Breast Cancer	Phase 2
Not yet recruiting	`NCT04034823` - KN035 in Combination With Trastuzumab and Docetaxel in HER2-positive Breast Cancer	Phase 2
Completed	`NCT04756921` - 18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response
Completed	`NCT03140553` - TCH Versus EC-TH as Neoadjuvant Treatment for HER2-Positive Breast Cancer	Phase 2
Completed	`NCT03094052` - Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib	Phase 2
Recruiting	`NCT05511844` - Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors	Phase 1
Recruiting	`NCT05325632` - Study of HER2 Directed Dendritic Cell (DC1) Vaccine + Weekly Paclitaxel, Trastuzumab & Pertuzumab	Phase 2
Recruiting	`NCT05710666` - Neoadjuvant Trastuzumab Deruxtecan (T-DXd) With Response-directed Definitive Therapy in Early Stage HER2-positive Breast Cancer (SHAMROCK Study)	Phase 2
Recruiting	`NCT06161922` - Real World Patient-Reported Outcomes in Chinese Her2+ EBC Patients Receiving (Neo) Adjuvant Anti-Her2 Based Therapy
Not yet recruiting	`NCT05063643` - Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude

NCT number	NCT06330012
Study type	Interventional
Source	Samsung Medical Center
Contact	Ji-Yeon Kim
Phone	82-2-3410-3459
Email	jyeon25@skku.edu
Status	Recruiting
Phase	N/A
Start date	March 18, 2024
Completion date	December 31, 2027

The Resistance Mechanism of Trastuzumab Deruxtexan in HER2 Positive Breast Cancer Patients.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms