Hepatocellular Carcinoma Clinical Trial
Official title:
Genetic and Molecular Basis of Pediatric Liver Cancer
NCT number | NCT03959800 |
Other study ID # | STUDY20050018 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | June 22, 2015 |
Est. completion date | June 30, 2029 |
The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Status | Recruiting |
Enrollment | 1600 |
Est. completion date | June 30, 2029 |
Est. primary completion date | June 30, 2028 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 0 Years to 99 Years |
Eligibility | Inclusion Criteria: - Prior or current treatment for a childhood liver tumor, malignant or benign, at age <21 years. - Biological parents and siblings of eligible children. Exclusion Criteria: - No prior or current treatment for a childhood liver tumor. - Non-biological parents, legal guardians, or non-biological siblings of eligible children. |
Country | Name | City | State |
---|---|---|---|
United States | UPMC Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Gene sequencing | DNA sequence variants | Recurrence free survival at 2 years | |
Primary | Gene expression analysis | Differentially expressed genes | Recurrence free survival at 2 years | |
Primary | Status of genome-wide chromatin accessibility | chromatin accessibility | Duration of active chemotherapy to two years after surgical treatment | |
Primary | Epigenetic change | Differential methylation | Duration of active chemotherapy to two years after surgical treatment | |
Primary | Tumor infiltrating cells which express immune checkpoints | differentially enriched immune cells | Duration of active chemotherapy to two years after surgical treatment | |
Secondary | Response to chemotherapy | Survival | Duration of active chemotherapy to two years after surgical treatment | |
Secondary | Response to chemotherapy | Relapse | Duration of active chemotherapy to two years after surgical treatment |
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