Pretreatment Lymphocyte Monocyte Ratio on Outcome HCC Patients

Hepatocellular Carcinoma Clinical Trial

Official title:

The Impact of Pretreatment Lymphocyte to Monocyte Ratio on Clinical Outcome for Patient With HCC

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03869151
• Other study ID #: 17200000
• Status: Not yet recruiting
• Start date: April 5, 2019
• Est. completion date: March 31, 2020

Study information

• Verified date: March 2019
• Source: Assiut University
• Contact: amany Amin, master
• Phone: +201093930042
• Email: dr.ma777moud[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To assess the prognostic role of pretreatment LMR in hepatocellular carcinoma(HCC).

Description:

The exact molecular mechanisms responsible for the prognostic impact of lymphocyte monocyte ratio in Heatocellular carcinoma are unclear.It has been suggested that cross-talk between the inflammatory response and tumor progression play a critical role in the initiation and progression of Heatocellular carcinoma. In the tumor microenvironment, inflammatory infiltrates have a large influence on the biological behavior of Heatocellular carcinoma.

Tumor-infiltrating lymphocytes, as representative component of the immune microenvironment ,are implicated in several stages of Heatocellular carcinoma progression, and Tumor-infiltrating lymphocytes phenotypes may be a predictor for favorable prognosis.

Conversely, low lymphocyte counts might result in an insufficient immunological reaction, which lead to inferior survival in multiple cancers.

Monocytes infiltrating tumor tissue are also involved in Heatocellular carcinoma development and progression. Activated monocytes in Heatocellular carcinoma micro environments can trigger and polarize T-cell responses and facilitate inflammation-induced tumor development.

Tumor-associated macrophages are derived from circulating monocytes. Tumor-associated macrophages can accelerate Heatocellular carcinoma cell proliferation,tumor-associated angiogenesis, and metastasis. Several studies showed that high infiltration of Tumor-associated macrophages predicted decreased survival in various cancers.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1
• Est. completion date: March 31, 2020
• Est. primary completion date: March 5, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

Patients with child A Hepatocellular carcinoma.

Exclusion Criteria:

• Patients with child C Hepatocellular carcinoma.

• Patients with heart failure

Related Conditions & MeSH terms

• Carcinoma, Hepatocellular
• Hepatocellular Carcinoma

Intervention

Diagnostic Test:
• CBC
lymphocyte and monocyte count

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Amany Aboalenen Amin

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	increased over all survival	Elevated pretreatment lymphocyte monocyte ratio may be a favorable prognostic factor for clinical outcomes in patients with hepatocellular carcinoma.	1 year