Hepatocellular Carcinoma (HCC) Clinical Trial
Official title:
Safety and Efficacy of Lenvatinib as an Adjuvant Therapy in Patients With Hepatocellular Carcinoma Following Radical Resection: A Single-Arm and Open-Label Prospective Study
Lenvatinib is the standard of care for patients with advanced hepatocellular carcinoma (HCC).
The aim of the single-arm, open-label, phase II clinical trial is to evaluate the efficacy
and safety of lenvatinib as an adjuvant therapy for patients underwent radical resection of
HCC with a high risk of tumor recurrence.
Investigator hypothesize that lenvatinib may be an effective adjuvant treatment for HCC, and
12-month adjuvant treatment with lenvatinib can improve one-year recurrence-free survival
rate (RFS) of HCC patients after surgical resection.
There's no widely accepted adjuvant therapy for patients with HCC. Lenvatinib, a
multi-targeted tyrosine kinase inhibitor, was approved for advanced or unresectable HCC. In
this study, investigators aim to evaluate the effects and safety of adjuvant apatinib therapy
for the patients who underwent curative resection for HCC with high risk of disease
recurrence.
Participants who underwent radical resection for HCC with high risk of tumor recurrence will
be recruited in this study. During 4 to 6 weeks after surgery, each participant will receive
a screening visit to exclude residual tumors. Each eligible participant will be treated with
lenvatinib until tumor recurrence, intolerant adverse effect, participant' refusal, or
completing 12-month treatment.
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