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Hepatitis clinical trials

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NCT ID: NCT04812990 Completed - Hepatitis C Clinical Trials

A Cross Sectional Observational Study on Relation Between Oral Manifestation and Hepatitis C in Egypt

Start date: March 1, 2021
Phase:
Study type: Observational

Hepatitis C virus (HCV) is the major cause of chronic liver disease and has a long-term resultant complications4 and it considered as a major endemic medical health problem in Egypt. It affects multiple organs and reflect various manifestations on oral cavity.The purpose of this study is to assess the prevalence of oral mucosa conditions, type of oral manifestation and gingival lesions in patients with hepatitis C

NCT ID: NCT04809246 Completed - Hepatitis C Clinical Trials

Prisons Evaluation of a One-stop-shop InterVentiOn

PIVOT
Start date: October 31, 2019
Phase: N/A
Study type: Interventional

A prospective historically controlled study to assess the effect of an intervention integrating point-of-care hepatitis C (HCV) RNA testing, non-invasive liver fibrosis assessment, fast-tracked direct-acting antiviral (DAA) prescription, and linkage to hepatitis care (a 'one-stop-shop' intervention), on the proportion of participants initiating DAA therapy among people who are recently incarcerated within reception correctional centre(s) in Australia.

NCT ID: NCT04798521 Completed - Hepatitis C Clinical Trials

TeleHepC Treatment Trial

Start date: June 30, 2020
Phase: N/A
Study type: Interventional

The main goal of this study is to test the efficacy of a peer-facilitated telemedicine HCV treatment implementation strategy for people who use drugs versus local HCV treatment referral for achieving HCV sustained viral response at 12 weeks post-treatment (SVR12).

NCT ID: NCT04774107 Completed - Clinical trials for Hepatitis C, Chronic

The Pharmacokinetics of P1101 + Ribavirin in Interferon Treatment-Naïve Subjects With Chronic Hepatitis C Virus (HCV) Genotype 2 Infection

Start date: November 26, 2020
Phase: Phase 1
Study type: Interventional

Primary Objective: To determine the P1101 pharmacokinetic (PK) profile at the single dose of 400 μg.

NCT ID: NCT04759521 Completed - Chronic Hepatitis B Clinical Trials

Evaluation of Liver Fibrosis With 2D-Shear Wave Elastography

Start date: January 3, 2019
Phase:
Study type: Observational [Patient Registry]

The aims of this study are to evaluate liver fibrosis with two-dimensional (2D) shear wave elastography (SWE) technique in inactive hepatitis B surface antigen (HBsAg) carriers and patients with active chronic hepatitis B (CHB), with the help of a propagation map, compare this method with histopathological results in patients with CHB and determine the suitability of 2D-SWE for use instead of liver biopsy by evaluating fibrosis before and after treatment.

NCT ID: NCT04757272 Completed - Clinical trials for Corona Virus Infection

Does Hepatitis C Management Protect Egyptian Population Against Severe Corona Virus Disease-2019?

Start date: May 1, 2020
Phase:
Study type: Observational

Modulation of the renin angiotensin system by the chronic hepatitis C virus treatment either by (Daclatasvir and Sofosbuvir), (Daclatasvir and Sofosbuvir plus Ribavirin), or (Ribavirin and Interferon) protocols could give an explanation for the low incidence of COVID-19 among Egyptian population. Adding it may play a role in COVID 19 prophylaxis.

NCT ID: NCT04749368 Completed - Clinical trials for Hepatitis B, Chronic

Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection

Start date: April 12, 2021
Phase: Phase 2
Study type: Interventional

This is an open label, randomized, parallel-group study to evaluate the safety and efficacy of combination treatment BRII-835 (VIR-2218) and BRII-179 (VBI-2601) in adult participants with chronic HBV infection

NCT ID: NCT04741750 Completed - Hepatitis C Clinical Trials

Increasing HCV Linkage to Care Among People Who Inject Drugs

Start date: February 2, 2021
Phase: N/A
Study type: Interventional

Our study will test the effectiveness of a simplified approach to delivering Hepatitis C Virus (HCV) care in a street-based mobile medical clinic among people who inject drugs in increasing treatment initiation, retention, and cure. Rates of HCV treatment initiation, retention, and cure will be compared between patients offered the simplified approach to delivering HCV care in a mobile medical clinic versus those who are linked to a community clinic delivering a current practice of usual care. The investigators hypothesize that the simplified approach to delivering HCV care in a street-based mobile medical clinic will result in higher treatment initiation, retention, and cure than the current practice of usual care in community clinics.

NCT ID: NCT04719338 Completed - Hepatitis C Clinical Trials

Occult HCV Infection After DAAD Treatment in Haemodialysis Patients

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

This research aims to evaluate the prevalence and predictors of Occult HCV among hemodialysis (HD) patients who achieved 24 weeks sustained virological response (SVR) after treatment with direct-acting antiviral agents (DAA) by detection of viral RNA in their peripheral blood mononuclear cells.

NCT ID: NCT04718831 Completed - Chronic Hepatitis b Clinical Trials

Spirulina (FEM-102) Supplement to Chronic Hepatitis B Patients

Start date: October 29, 2019
Phase: N/A
Study type: Interventional

Hepatocellular carcinoma (HCC), listed among lung and breast cancers as the top-ten cancer in 2016 Taiwan, is the second most prevalent cancer, just one place below colon cancer. Due to mass hepatitis B vaccination and the screening and therapeutic plan against hepatitis B and C viruses (HBV and HCV, respectively), the incidence of liver cancer drops significantly, however, still around twenty out of per hundred thousand population die from liver cancer each year. For patients suffering HBV and HCV, the prevention of HCC is a crucial health issue.