Evaluation of Liver Fibrosis With 2D-Shear Wave Elastography

Status Completed

Clinical Trial Summary

The aims of this study are to evaluate liver fibrosis with two-dimensional (2D) shear wave elastography (SWE) technique in inactive hepatitis B surface antigen (HBsAg) carriers and patients with active chronic hepatitis B (CHB), with the help of a propagation map, compare this method with histopathological results in patients with CHB and determine the suitability of 2D-SWE for use instead of liver biopsy by evaluating fibrosis before and after treatment.

Clinical Trial Description

A total of 253 patients with CHB and inactive HBsAg carriers as well as a control group of 30 healthy individuals were included in the study between January 2019 and October 2020. Liver stiffness measurements with 2D-SWE, fibrosis-4 (FIB-4) and aspartate aminotransferase to platelet ratio index (APRI) scoring and additional liver biopsy in patients with CHB were performed in all cases with the help of the propagation map. Depending on the degree of fibrosis, liver stiffness was measured again at 24 and 48 weeks in patients who received antiviral therapy. Spearman rank correlation test was used for analysing correlation between variables, and receiver operating curve analysis was used to evaluate diagnostic performance in terms of fibrosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04759521
Study type	Observational [Patient Registry]
Source	Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Contact
Status	Completed
Phase
Start date	January 3, 2019
Completion date	December 18, 2020

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