Hepatitis C Clinical Trial
Official title:
Evaluation of Liver Fibrosis by Serum Hyalornic Acid Measurement in β-Thalassemic Children Infected With Hepatitis C Virus Before and After Direct-Acting Antiviral Therapy
Verified date | May 2019 |
Source | Tanta University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Patients with transfusion dependent Beta Thalassemia suffer from a high incidence of Hepatitis C infection especially in developed countries as Egypt. In our patients we also found a high correlation between hepatitic C infection and Liver fibrosis. in this study we offer our patients treatment with Direct antiviral drugs and assessed the degree of fibrosis before and after treatment. We tested Hyalornic acid as a predictor of the degree of fibrosis before and after treatment.
Status | Completed |
Enrollment | 50 |
Est. completion date | March 1, 2019 |
Est. primary completion date | December 31, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 12 Years to 18 Years |
Eligibility |
Inclusion Criteria: - ß-thalassemic children with superadded hepatitis C virus infection Exclusion Criteria: 1. Liver decompansatoin. 2. Children <12years old. 3. Patients with viral hepatitis B |
Country | Name | City | State |
---|---|---|---|
Egypt | Pediatric Hematology Unit, Faculty of Medicine, Tanta University | Tanta | Gharbia Governorate |
Lead Sponsor | Collaborator |
---|---|
Tanta University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Treatment of Hepatitis C | Becoming PCR negative for Hepatitis C | 24 weeks | |
Secondary | Reduction of liver fibrosis | improvement of Fibroscan and Hyalornic Acid Level significantly after treatment | 6 months |
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