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DAA Treatment in Donor HCV-positive to Recipient HCV-negative Heart Transplant

Hepatitis C Clinical Trial

Official title:
Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Heart Transplant

Clinical Trial Summary

This is a proof of concept, single center study for the donation of HCV-positive hearts to HCV negative recipient patients, with preemptive, interventional treatment with 12 weeks of commercially available DAA therapy to prevent HCV transmission upon transplantation.

Clinical Trial Description

The goal of this study is to determine if preoperative dosing and sustained administration of pan-genotypic DAA therapy after cardiac transplantation prevents the transmission of hepatitis C virus (HCV) infection from an HCV-positive donor heart to an HCV naïve recipient. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03208244
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Terminated
Phase Phase 4
Start date November 9, 2017
Completion date April 28, 2021
View Details
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