Hepatitis C Clinical Trial
Official title:
Study of Quadruple Therapy With Eltrombopag for Chronic Hepatitis C
This study will provide chronic hepatitis C patients with low platelets (less than 75x10^9/L)
the opportunity to undergo treatment and possible cure of their virus. The main hepatitis C
drugs will be administered as standard of care, with the addition of the study drug
eltrombopag.
The investigators hypothesize that providing eltrombopag to chronic hepatitis C patients with
low platelets (less than 75x10^9/L) will permit the initiation and completion of antiviral
triple therapy with boceprevir, ribavirin, and pegylated-interferon.
SQUELCH-C is an investigator-initiated, single arm, non-blinded pilot study on the use of
eltrombopag in combination with ribavirin, pegylated-interferon, and boceprevir, for patients
who would not otherwise be treatment candidates because of low platelet counts (less than
75x10^9/L).
Administration of the drugs ribavirin and boceprevir will be standard of care, with one
exception for interferon.
The total drug treatment period for the study patient will range from 32 - 56 weeks,
depending on liver disease stage and viral response. Follow-up will take place at 12 and 24
weeks post treatment to evaluate for sustained viral response. Total study participation may
require 1.5 years.
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