Hepatitis C Clinical Trial
Official title:
Molecular Basis of Interferon Response in HCV
The purpose of this study is to evaluate what happens to hepatitis C virus in response to
treatment with pegylated interferon and ribavirin in patients with HCV compared to those
with HIV and HCV.
This research is being done to help us identify how the composition of HCV changes with
interferon in different populations. We will examine how quickly HCV is cleared from your
body and what factors may influence that clearance. This information may help us find better
treatments for HCV.
All patients who participate in this study will have frequent blood drawn in order to
measure how quickly HCV virus declines. Pegylated interferon and ribavirin are not provided
by the study, but will be obtained as part of standard of care treatment for hepatitis C.
Participants must be willing to spend 48 hours in the hospital for frequent blood draws.
They will be compensated for their time.
All patients must be HCV genotype 1. All patients must have a liver biopsy prior to
enrollment into study. (This is not provided by the study).
HIV-infected patients must have a CD4 cell count>300. If HIV-infected and on antiretroviral
therapy for HIV, they must be on a stable regimen for 12 weeks. The HIV regimen can not
include didanosine (Videx).
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Observational Model: Cohort, Time Perspective: Prospective
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