Hepatitis C Clinical Trial
Official title:
FGL2/Fibroleukin and Hepatitis C Virus Infection: A Predictor of HCV Recurrence and Progression Post Liver Transplantation
The main objective of this study is to assess whether a recently-developed bioassay for the molecule "secreted fibrinogen-like protein 2" (sFGL2) can be used to predict the recurrence and/or progression of Hepatitis C Virus disease in post liver transplant patients. The hypothesis is that patients with chronic HCV have higher than normal levels of sFGL2 in their blood both pre- and post-transplantation and that this will inhibit their ability to clear HCV, and influence the progression of HCV disease when it recurs.
Hepatitis C Virus infection (HCV) is a serious health problem worldwide, accounting for
significant morbidity and mortality. The current treatment, combination therapy with
pegylated IFNa/ribavirin results in only a 50% sustained viral response such that HCV is now
the leading indication for liver transplantation. Unfortunately, HCV recurrence
post-transplantation is universal and it is often difficult to distinguish recurrent HCV
from other processes such as rejection, leading to inappropriate or delayed treatment(s) and
compounding graft damage. It would be beneficial to have access to a circulating biomarker
to distinguish HCV disease recurrence from other processes and to predict the severity of
HCV disease progression post-transplantation.
The molecule FGL2 is secreted by cells of the immune system and may be a key immunomodulator
affecting graft survival and HCV recurrence. The aim of this study is to assess whether a
bioassay for FGL2 can predict HCV disease recurrence and progression after liver
transplantation and/or differentiate HCV disease recurrence from acute cellular rejection.
This study will also examine the form of Fc Receptor expressed in these patients. The Fc
receptor is hypothesized to be the binding partner of FGL2.
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Observational Model: Case Control, Time Perspective: Prospective
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