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Clinical Trial Summary

The purpose of this study is to determine the safety, tolerability and pharmacokinetics of ALN-HBV in healthy adult volunteers and patients with chronic hepatitis B virus (HBV) infection. In addition, the study will assess antiviral efficacy of ALN-HBV in patients with HBV.


Clinical Trial Description

The study has 3 parts. Part A is a single ascending dose (SAD) study in healthy volunteers. Part B is a single ascending dose study (SAD) in patients with HBV infection. Part C is a multiple ascending dose study (MAD) in patients with HBV infection. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02826018
Study type Interventional
Source Alnylam Pharmaceuticals
Contact
Status Terminated
Phase Phase 1
Start date June 24, 2016
Completion date October 2017

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