Metastatic Colorectal Cancer: Treatment Response With Dynamic Contrast MRI

Colorectal Neoplasm Clinical Trial

Official title: Angle Interleaved Projection Reconstruction With K-Space Weighted Image Reconstruction for Dynamic Contrast MRI of Cancer Therapy Response

Status Terminated

Clinical Trial Summary

The objectives for this study include:

• Testing a unique way of imaging people with colorectal cancer and other cancers that has spread to the liver using magnetic resonance imaging (MRI);

• Seeing if the MRI process can be used across multiple imaging platforms;

• Determining whether the results of the imaging can be reproduced;

• Reviewing how MRI results relate to cancer response to combination therapy and to clinical endpoints.

Clinical Trial Description

This study will investigate the use of projection reconstruction dynamic contrast-enhanced MRI (DCE-MRI) as a surrogate marker of tumor vascularity in patients treated with the antiangiogenic agent bevacizumab. DCE-MRI is gaining popularity as a method to assess the functional response of tumors to agents targeting the vascular endothelial growth factor (VGEF) pathways. DCE-MRI measurements have been proposed as a non-invasive measure of both tumor biologic activity and (in the case of antivascular therapy) early response to treatment. A number of phase I and II studies demonstrate the ability for DCE-MRI to detect perfusion changes associated with tumor biologic response to vascularly targeted agents. It has been suggested that pre-treatment DCE-MRI might identify tumors with high intrinsic perfusion and that these tumors will be more likely to respond to antivascular-based therapies. However, the current use of DCE-MRI in clinical settings is challenging. Trade-offs between spatial coverage, time, and spatial resolution make this technique difficult to implement in human studies and may limit its reliability. The use of projection reconstruction-based acquisition can mitigate the need for these trade-offs and can simultaneously provide high temporal and spatial resolution data for DCE-MRI analysis. ;

Related Conditions & MeSH terms

• Colorectal Neoplasm
• Colorectal Neoplasms
• Hepatic Neoplasm
• Liver Neoplasms
• Neoplasms

• NCT number: NCT00820456
• Study type: Observational
• Source: American College of Radiology
• Status: Terminated
• Start date: April 2008
• Completion date: December 31, 2009