Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Hepatectomy Clinical Trial

Official title:

Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05246371
• Other study ID #: Ain Shams anesthesia Dep
• Status: Recruiting
• Phase: Early Phase 1
• Start date: June 1, 2021
• Est. completion date: November 2023

Study information

• Verified date: January 2023
• Source: Ain Shams University
• Contact: ola Lashin, Master
• Phone: 00201026034100
• Email: Ola.lashin[@]med.asu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Description:

Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity.

Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: November 2023
• Est. primary completion date: November 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. Patients American Society of Anesthesiologists physical status (ASA) I to II.

2. Patients Child Pugh classification A to B.

3. Both sexes.

4. Aged between 18 years and 70 years

5. Scheduled for more than 1 segment hepatectomy.

Exclusion Criteria:

1. Patients with Child Pugh classification C.

2. Patients younger than18 years old or older than 70 years old

3. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).

4. Prior liver resection for donation.

5. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).

6. Hypersensitivity to any of the used drugs.

Related Conditions & MeSH terms

• Hepatectomy

Intervention

Drug:
• Propofol, dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.
• Desflurane
Patients will receive maintenance of general anesthesia by desflurane.

Locations

Country	Name	City	State
Egypt	Ain Shams University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	aspartate aminotransferase (AST)	aspartate aminotransferase (AST)	1 week
Primary	alanine aminotransferase (ALT)	alanine aminotransferase (ALT)	1 week
Primary	bilirubin	bilirubin	1 week
Primary	albumin	albumin	1 week
Primary	prothrombin time	prothrombin time	1 week
Primary	INR	INR	1 week