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NCT00328900 Clinical Trial

Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine

Hemorrhoids Clinical Trial

Clinical Trial Details — Status: Unknown status

Administrative data
NCT number NCT00328900
Other study ID # S-03113
Secondary ID
Status Unknown status
Phase N/A
First received May 22, 2006
Last updated May 31, 2012
Start date January 2006

Study information
Verified date April 2007
Source Rikshospitalet University Hospital
Contact Hanne Storm, PhD
Phone +47 23074398
Email hanne.storm@medisin.uio.no
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.

Description:

Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.

Recruitment information / eligibility
Status Unknown status
Enrollment 24
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients in ASA-group 1-2

- Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour

- informed consent

- BMI <30

Exclusion Criteria:

- Patients using any medication known to influence the autonomous nervous system

- Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)

- BMI >30

- Pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Administration of 0,7 mg of atropine

Device:
• Measurement of skin conductance with Pain detector

Locations
Country Name City State
Norway Ulleval University Hospital Oslo

Sponsors (1)
Lead Sponsor Collaborator
Rikshospitalet University Hospital

Country where clinical trial is conducted

Norway, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of skin conductance fluctuations
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