Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease

Hemorrhoid Pain Clinical Trial

Official title: Efficacy and Safety of CONAN® Proctological Cream Formulation in the Topical Treatment of Haemorrhoidal Disease and Anal Fissures: a Randomized Controlled Clinical Trial

Status Completed

Clinical Trial Summary

Aim of the study is to assess the efficacy, safety and tolerability of CONAN® (Proctological Cream, Medical Device, Omikron Italia Srl) on most frequent symptoms in grade 1-2 of haemorrhoidal disease and anal fissures.

Clinical Trial Description

Background: To evaluate the role of CONAN® Proctological Cream containing escin, hesperidin and hyaluronic acid in topical treatment of haemorrhoidal disease and anal fissures and its potential efficacy in reducing related symptoms.

Methods: Forty patients with haemorrhoidal disease and anal fissures were enrolled. Of them, 20 were randomized to receive the medical device CONAN® Cream (Group A) and 20 to the untreated control group (Group B). At each scheduled visit, total symptoms were assessed and recorded by assigning a Numerical Rating Scale score from 0 to 10. The adverse events reported by study subjects were also assessed and recorded. ;

Related Conditions & MeSH terms

• Hemorrhoid Pain
• Hemorrhoids
• Inflammation

• NCT number: NCT05984641
• Study type: Interventional
• Source: Omikron Italia S.r.l.
• Status: Completed
• Phase: N/A
• Start date: March 1, 2022
• Completion date: September 30, 2022