Hemorrhage Clinical Trial
Official title:
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation Rates in Post-Operative Cardiac Surgery Patients
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
Atrial fibrillation (AF) is a common complication of cardiac surgery. It has been shown that
the onset of AF increases in post-operative cardiac surgery population. The rate of AF after
coronary artery bypass graft (CABG) procedure range from 10-65% and from 37-50% after valve
surgery. Rates of new onset AF are lower for CABG compared to valve procedures. The
pathophysiology of post-operative AF is not well elucidated. It has been postulated that
pre-operative factors such as age, past medical history, operative and post-operative
remodeling of the coronary system and hemodynamic pressure changes may contribute to
post-operative AF.
Ranolazine is currently approved as an antianginal drug. The antianginal properties of the
drug are due to inhibition of the late inward sodium current. Through the same mechanism it
has been demonstrated in animal experiments and human studies that it can prevent atrial and
ventricular arrhythmias.
Therefore it is important to prevent or minimize the incidence of new onset post-operative
AF in post-surgical population.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention
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