| Eligibility |
INCLUSION CRITERIA:
- Age 18 to 82 years (inclusive) at the time of signing the ICF.
- Participants will be classified at screening by renal function based on eGFR as
calculated by the MDRD formula and requirement for HD (Group 5).
- Participants eligible for Group 5 with ESRD have received HD for at least 3 months
prior to screening.
- Participants eligible for Group 1 should be in good health as determined by no
clinically significant deviations from normal for medical history, physical
examination, vital signs,12-lead ECGs, or clinical laboratory determinations at
screening or Day -1.
- Participants eligible for Groups 2 through 5 may have medical findings consistent with
their degree of renal dysfunction, as determined by medical history, physical
examination, vital signs, 12-lead ECGs, and clinical laboratory determinations at
screening and Day -1 (Groups 2 through 4) or Period 1, Day -1 (Group 5). Participants
with abnormal findings considered not clinically significant by the medical monitor or
investigator are eligible.
- Body mass index within the range 18.0 to 40.0 kg/m2 (inclusive) at screening.
- Willingness to avoid pregnancy or fathering children based on the criteria defined in
the protocol.
- Ability to swallow and retain oral medication.
EXCLUSION CRITERIA:
- History of uncontrolled or unstable cardiovascular, respiratory, hepatic, GI,
endocrine, hematopoietic, psychiatric, and/or neurological disease within 6 months of
screening.
- Evidence of rapidly deteriorating renal function.
- Participants who have a current, functioning organ transplant or have a scheduled
organ transplant within 6 weeks after check-in.
- History of malignancy within 5 years of screening, with the exception of cured basal
cell carcinoma, squamous cell carcinoma of the skin, ductal carcinoma in situ, or
Gleason 6 prostate cancer.
- History of clinically significant GI disease or surgery (cholecystectomy and
appendectomy are allowed) that could impact the absorption of study drug.
- Participants eligible for Group 1 who have a history of renal disease or renal injury
as indicated by an abnormal, clinically significant renal function profile at
screening or Day -1.
- Participants eligible for Groups 2 through 5 who have had a change in disease status
within 30 days of screening, as documented by the participant's medical history and
deemed clinically significant by the investigator.
- History or current diagnosis of uncontrolled or significant cardiac disease indicating
- significant risk of safety for participation in the study, including any of the
following:
1. Recent myocardial infarction (within 6 months of check-in).
2. New York Heart Association Class III or IV congestive heart failure.
3. Unstable angina (within 6 months of check-in).
4. Clinically significant (symptomatic) cardiac arrhythmias (eg, sustained
ventricular tachycardia, second or third degree atrioventricular block without a
pacemaker).
5. Uncontrolled hypertension.
- Any major surgery within 4 weeks of screening.
- Donation of blood to a blood bank within 4 weeks of screening (within 2 weeks for
- plasma only).
- Blood transfusion within 4 weeks of Day -1 (for Groups 1 through 4) or Period 1,
- Day -1 (Group 5).
- Chronic or current active infectious disease requiring systemic antibiotic,
antifungal, or antiviral treatment.
- Positive test and symptomatic for HBV, HCV, or HIV. Participants whose results are
compatible with prior immunization for or immunity due to infection with HBV may be
included at the discretion of the investigator.
- Participants eligible for Group 1 who have a history of using tobacco- or nicotine
containing products within 6 months of screening.
- Participants eligible for Groups 2 through 5 who smoke > 10 cigarettes per day or
equivalent use of other tobacco- or nicotine-containing products and are unwilling to
refrain from tobacco or nicotine use on dosing days and abide by CRU restrictions.
- History of alcohol dependency within 3 months of screening.
- Positive breath test for ethanol or positive urine or saliva screen for drugs of abuse
(confirmed by repeat) at screening or check-in that are not otherwise explained by
permitted concomitant medications.
- Current treatment or treatment within 30 days or 5 half-lives (whichever is longer) of
study drug administration with another investigational medication or current
enrollment in another investigational drug study.
- Current treatment or treatment within 30 days or 5 half-lives (whichever is longer) of
study drug administration with strong or moderate inducer or inhibitor of CYP3A4 or
P-gp (refer to the Drug Interaction Database Program [University of Washington School
of Pharmacy 2002] for prohibited drugs).
- Participants eligible for Group 1 who have used prescription drugs within 14 days of
study drug administration or nonprescription medications/products (including vitamins,
minerals, and phytotherapeutic/herbal/plant-derived preparations) within 7 days of
study drug administration. However, occasional acetaminophen and ibuprofen are
permitted.
- Participants eligible for Groups 2 through 5 who have used prescription drugs within
14 days of study drug administration, with the exception of established therapy for
renal disease and the treatment of associated disorders that have been stable for at
least 7 days prior to study drug administration, as approved by the investigator and
in consultation with the sponsor's medical monitor.
- Current or recent history (within 30 days before screening) of a clinically
significant bacterial, fungal, parasitic, or mycobacterial infection, or currently
receiving systemic antibiotics. Current clinically significant viral infection at
screening or check-in.
- History of any significant drug allergy (such as anaphylaxis or hepatotoxicity) deemed
clinically relevant by the investigator.
- Inability to undergo venipuncture or tolerate venous access.
- Participants eligible for Group 5 who are not expected to continue HD treatment for
the duration of the study.
- Receipt of live (including attenuated) vaccines within 3 months of check-in or
- anticipation of need for such a vaccine during the study (Note: nonlive or inactivated
vaccines are allowed up to 2 weeks prior to the first dose of study drug).
- Known hypersensitivity or severe reaction to INCB000928 or excipients of
INCB000928(refer to IB).
- Inability or unlikeliness of the participant to comply with the dose schedule and
study evaluations, in the opinion of the investigator.
- Any condition that would, in the investigator's judgment, interfere with full
participation in the study, including administration of study drug and attending
required study visits;pose a significant risk to the participant; or interfere with
interpretation of study data.
- Women who are pregnant or breastfeeding.
- QTc > 450 milliseconds for Groups 1 through 3 and QTc > 470 milliseconds for Group 4.
- Participants eligible for Group 1 who have abnormal LFT values, defined as aspartate
aminotransferase, alanine aminotransferase, and serum (total and direct) bilirubin, as
well as amylase and lipase above the upper limit of the normal range at screening.
- Participants eligible for Groups 2 through 4 who have values outside the normal ranges
for LFTs; however, values may be acceptable if they are consistent with the
participant's renal condition (if stable for 1 month prior to screening) and if the
investigator (or designee) and the sponsor feel that the results are not clinically
significant (based on age and renal impairment status).
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