Hemodialysis Clinical Trial
Official title:
The Impact of Different Dialysis Modalities on Right Ventricular Function in End-stage Renal Disease Patients
NCT number | NCT04524468 |
Other study ID # | 2019-398 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2019 |
Est. completion date | July 1, 2020 |
Verified date | August 2020 |
Source | Antalya Training and Research Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Right ventricular (RV) dysfunction is a major cause of heart failure and mortality in end-stage renal disease (ESRD) patients. The aim of the study was to evaluate the long-term impacts of different dialysis modalities on RV function assessed by conventional echocardiography in ESRD patients with preserved left ventricular function. The study included 83 ESRD patients grouped as follows: peritoneal dialysis (PD; n=46) and hemodialysis with brachial arterio-venous fistula (HD; n=37). Conventional echocardiography including 2D and tissue Doppler imaging was performed in all patients. Echocardiographic parameters were compared between groups.
Status | Completed |
Enrollment | 83 |
Est. completion date | July 1, 2020 |
Est. primary completion date | March 1, 2020 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - End-stage renal disease patients on a regular dialysis program - Being on dialysis at least 6 months - >18 years old Exclusion Criteria: - Ischemic heart disease - Left ventricular systolic dysfunction with an ejection fraction (EF) of less than 55 % - Valvulopathy - Left bundle branch block - Atrial fibrilation - Previous renal transplantation - Chronic obstructive pulmonary disease - Interstitial lung diseases - Connective tissue disorders - Chronic thromboembolic disease - Congenital left-to-right shunt - Primary pulmonary hypertension |
Country | Name | City | State |
---|---|---|---|
Turkey | Antalya Research and Training Hospital | Antalya |
Lead Sponsor | Collaborator |
---|---|
Antalya Training and Research Hospital |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Estimation of right ventricular function in end-stage renal disease patients | Transthoracic echocardiography was performed to end-stage renal disease patients on hemodialysis and peritoneal dialysis for at least 6 months. Tricuspid annular plane systolic excursion (TAPSE), right ventricular fractional area change (RV FAC), Right ventricular myocardial performance index (RV MPI) and right ventricular lateral peak annular systolic velocity (Sa) were measured to estimate right ventricular function. | 1 week |
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