Hemodialysis Clinical Trial
Official title:
The Effect of Citrate Dialysate on Clot Formation and Anemia in Hemodialysis Patients
Acetate-free citrate containing dialysate is expected to be clinically effective in maintaining hemodynamic stability during hemodialysis (HD). It has been demonstrated that citrate dialysate help produce a local anticoagulant effect by chelating ionized calcium. Moreover, citrate can improve phosphate and beta2 macroglobulin and better control of arterial hypertension and hemoglobinemia. We therefore would like to study the effect of citrate dialysate on clot formation and anemia while reducing heparin in chronic hemodialysis patients.
This is the prospective comparison study. This study enrolled chronic hemodialysis patients
age more than 18 who undergo hemodialysis 3 times per week for at least 3 months. All the
patients should have serum ferritin 200-1000 ng/L and TSAT of 15-50%. The investigators
exclude patients with age more than 70 years, comorbidities influencing citrate metabolism
(hepatic failure,liver transplantation,cancer with bone metastasis), patients using heparin
free protocol, hyperkalemia worsened by hypocalcemia, contraindication to heparin, treatment
with cinacalcet or oral anticoagulant, patients using central venous catheter with blood flow
less than 300 ml/min, and patients using low molecular weight heparin.
The study will be conducted in three phases over a period of 4 months. After run-in period
for 2 weeks using acetate dialysate, the heparin dose will be titrated to lowest effective
dose. During the first phase, citrate was replaced for acetate and heparin will be reduced to
50%. The second and third phase will be performed by reducing heparin doses to 25 % and
heparin free consecutively. Each phase lasts for 4 weeks. Washout period for 2 weeks will be
alternated after each phase.
Data collection: The investigators measure blood chemistries such as CBC, BUN creatinine
electrolytes calcium phosphorus and KT/V at the beginning and at the end of each session.
Ionized calcium will be monitored pre and post dialysis in each session. In addition, the
investigators record clot score and erythropoietin dosage in each session and each phase.
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