Hemodialysis Clinical Trial
Official title:
Altering Bicarbonate Delivery During Hemodialysis to Affect Filtration of Indoxyl Sulfate
Verified date | July 2017 |
Source | New York University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is a non randomized crossover trial investigating whether changing the pattern of bicarbonate administration during hemodialysis will result in the more efficient filtration of highly protein bound solutes. The experimental group will be dialyzed with low bicarbonate dialysate for the first half of dialysis then switched over to normal bicarbonate dialysate for the second half. The control group will be dialyzed entirely with normal bicarbonate dialysate. The two groups will switch one week late and patients will serve as their own matched controls for a completely standard dialysis and one that is split into two halves with different bicarbonate concentrations.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | July 1, 2017 |
Est. primary completion date | July 1, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Chronic Stable Dialysis for at least 6 months Exclusion Criteria: - Patients with serum potassium concentration below 4.0 mEq/L on previous monthly lab test or corrected serum calcium below 8.5 mEq/L - Hospitalization within the past 12 months - Adults unable to consent - Children - Pregnant women - Prisoners |
Country | Name | City | State |
---|---|---|---|
United States | New York University School of Medicine | New York | New York |
Lead Sponsor | Collaborator |
---|---|
New York University School of Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the amount of Indoxyl Sulfate level in the first half of dialysis as compared to controls | 1 Minute, 75 Minutes, 105 Minutes, 180 Minutes, 210 Minutes | ||
Secondary | Change in pH | 1 Minute, 75 Minutes, 105 Minutes, 180 Minutes, 210 Minutes |
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