Hemodialysis Patients Clinical Trial
Official title:
Impact on the Proteolysis of Obesity in Dialysis
The objective of this study is to determine whether obesity has a protective effect on muscle proteolysis in hemodialysis patients submitted to a short starvation. This effect will be tested by comparing measuring muscle proteolysis, using regional infusion of a tracer amino acid (D5 phenylalanine) in two groups of obese and non-obese patients compared to obese and non-obese control subjects.
In hemodialysis patients, the risk of death decreases almost linearly as BMI increases,
including in obese patients. Experimental data suggest that obesity may be associated with a
reduction of muscle proteolysis during fasting.
In the hemodialysis patients, after an overnight fast an increased use of endogenous energy
stores has been reported. The objective of the study is to evaluate the potentially
"protective" effect of obesity on protein catabolism during short fasting periods.
Twenty non diabetic patients (men and women) on maintenance hemodialysis for more than six
months, aged of 30 to 70 years, will be included: 10 obese (BMI ≥ 30) and 10 non obese
patients (18.5 <BMI <25) will be compared with 20 healthy volunteers (men and women) aged 30
to 70 years, obese and non obese, according to the same criteria.
On the investigation day, tracer kinetic studies will be associated with resting energy
expenditure measurements and body composition analysis (using dual energy x-ray
absorptiometry (DXA).
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06382701 -
Effect of Aromatherapy on Pain, Anxiety and Satisfaction in Cannulation
|
N/A | |
| Completed |
NCT04674930 -
Effects of Exercise Program on Physical Functioning of Hemodialysis Patients.
|
N/A | |
| Recruiting |
NCT02245633 -
Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients
|
N/A | |
| Recruiting |
NCT01970280 -
Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients.
|
Phase 4 | |
| Completed |
NCT06165211 -
Nature-Based Sound Application For Hemodialysis Patients
|
N/A | |
| Completed |
NCT05693584 -
The Effect of Using Virtual Reality Glasses on Pain During Fistula Cannulation in Hemodialysis Patients
|
N/A | |
| Completed |
NCT06106763 -
Mandala Colouring On Anxiety, Depression, Pain And Quality of Life
|
N/A | |
| Completed |
NCT01932853 -
Association Between Dose Dialysis by Kt and Mortality
|
N/A | |
| Completed |
NCT01273974 -
The Immunogenicity of Intradermal Influenza Vaccination in Hemodialysis Patients
|
Phase 2/Phase 3 | |
| Completed |
NCT04139759 -
THE EFFECT OF HAND AND FOOT MASSAGE ON FATIGUE IN HEMODIALYSIS PATIENTS
|
N/A | |
| Not yet recruiting |
NCT05574595 -
Effect on Pain and Comfort Associated With Fistula Puncture
|
N/A | |
| Completed |
NCT04175652 -
Effects of Laughter Yoga on Hemodialysis Patients' Plasma-Beta Endorphin Levels, Pain Levels and Sleep Quality
|
N/A | |
| Not yet recruiting |
NCT06314243 -
The Impact of Pumpkin Seed Oil Supplementation on Hemodialysis Patients
|
Phase 3 | |
| Completed |
NCT01596842 -
Effect of Omega-3 Fatty Acid on Vitamin D Activation
|
Phase 4 | |
| Enrolling by invitation |
NCT01896882 -
Dietary Sodium Restriction in Hemodialysis Patients
|
N/A | |
| Completed |
NCT00638300 -
Removal of Ligand-bound Iron During Intravenous (IV) Iron Administration in Hemodialysis (HD)
|
N/A | |
| Terminated |
NCT00259714 -
Dialysate Sodium Individualization in Hemodialysis
|
Phase 1 | |
| Completed |
NCT01846754 -
Prevalence of Fatigue in Hemodialysis Patients
|
N/A | |
| Completed |
NCT00491868 -
Clinical Study of R744 to Hemodialysis Patients
|
Phase 3 | |
| Completed |
NCT04195919 -
The Pharmacokinetics/Pharmacodynamics and Safety/Tolerability of Evogliptin in Hemodialysis Patients
|
Phase 1 |