Clinical Trials Logo
  1. Home
  2. Hemifacial Spasm
  3. NCT01598961

Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery

Hemifacial Spasm Clinical Trial

Official title:
Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery

Clinical Trial Summary

There have been reports of monitoring LSR during MVD surgery helps predicting the clinical outcome of MVD.However, there have been no evidence of which degree of partial neuromuscular blockade should be performed or no neuromuscular blockade could be performed during LSR monitoring. Therefore, we performed a randomized controlled trial to evaluate the effect of different degree of partial neuromuscular blockade, including no neuromuscular blockade on the LSR monitoring for MVD surgery.

Clinical Trial Description

Hemifacial spasm develops by vascular compression of facial nerve at the root exit zone from brain stem. Microvascular decompression (MVD) is known for its curative treatment. Lateral spread response (LSR) is a kind of pathologic electromyographic (EMG) wave form which develops when facial nerve is compressed by vessel. There have been reports of monitoring LSR during MVD surgery helps predicting the clinical outcome of MVD.

As neuromuscular blockade during LSR monitoring decreases the amplitude of EMG, partial neuromuscular blockade is usually maintained during general anesthesia for MVD. However, there have been no evidence of which degree of partial neuromuscular blockade should be performed or no neuromuscular blockade could be performed during LSR monitoring. Therefore, we performed a randomized controlled trial to evaluate the effect of different degree of partial neuromuscular blockade, including no neuromuscular blockade on the LSR monitoring for MVD surgery. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01598961
Study type Interventional
Source Samsung Medical Center
Contact
Status Completed
Phase N/A
Start date May 2012
Completion date April 2013
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04474977 - Microvascular Decompressive Surgery for Hemifacial Spasm
Withdrawn NCT01932255 - CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap N/A
Completed NCT00210431 - Post Marketing Surveillance Study of Dysport
Recruiting NCT03306940 - Botulinum Toxin A in the Treatment of Hemifacial Spasm N/A
Completed NCT05103202 - Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Unknown status NCT01726725 - Hemifacial Spasm and Desflurane N/A
Not yet recruiting NCT06195241 - Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm Phase 4
Not yet recruiting NCT04589364 - Study of Abobotulinum Toxin Versus Neubotulinum Toxin Injection For Hemifacial Spasm in Thai Patients Phase 3
Completed NCT01613781 - Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery N/A
Completed NCT03508882 - Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm Phase 4
Enrolling by invitation NCT01271634 - Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients N/A
Recruiting NCT04645277 - Magnetic Resonance Imaging Study on Patients With Hemifacial Spasm
Completed NCT03390803 - Effect of Hemifacial Spasm on Intraocular Pressure Measurement N/A
Completed NCT01728428 - A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients N/A
Completed NCT04621578 - Transcutaneous Electrical Acupoint Stimulation on Postoperative Dizziness in Hemifacial Spasm Patients N/A
Completed NCT00276315 - Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm Phase 3
Completed NCT02761096 - Effect of Acupuncture on Inflammation and Immune Function After Craniotomy N/A
Not yet recruiting NCT01546805 - Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm N/A
Unknown status NCT01564979 - Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm Phase 2
Completed NCT01168388 - Movement Disorder Survey in East China N/A