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Acalabrutinib for the Treatment of Chronic Graft Versus Host Disease

Hematopoietic and Lymphoid Cell Neoplasm Clinical Trial

Official title:
Acalabrutinib for Chronic Graft-Versus-Host Disease

Clinical Trial Summary

This phase II trial studies how well acalabrutinib works in treating patients with chronic graft versus host disease. Acalabrutinib may be an effective treatment for graft-versus-host disease caused by a stem cell transplant.

Clinical Trial Description

OUTLINE: Patients receive acalabrutinib orally (PO) twice daily (BID) on days 1-28. Treatment repeats every 28 days for up to 6 cycles with an option to continue for up to 24 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 30 days and then periodically thereafter. ;

Study Design

Related Conditions & MeSH terms

  • Bronchiolitis Obliterans Syndrome
  • Graft vs Host Disease
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Recurrent Moderate-Severe Chronic Graft Versus Host Disease
Clinical Trial Details
NCT number NCT04198922
Study type Interventional
Source Fred Hutchinson Cancer Center
Contact Gaby Desatnik
Phone 206-667-1356
Email chronicGVHDstudies@fredhutch.org
Status Recruiting
Phase Phase 2
Start date December 12, 2020
Completion date January 31, 2027
View Details
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