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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04841447
Other study ID # 2018932
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date March 20, 2020
Est. completion date March 20, 2026

Study information

Verified date April 2023
Source University of Missouri-Columbia
Contact Xunlei Kang, MD.PhD
Phone 5738844524
Email kangxu@health.missouri.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute myeloid leukemia (AML) accounts for more than 40% of leukemia mortality in the United States. Each year around ten thousand people die from the disease, most within a few years of diagnosis. Despite advances in our understanding of the disease, few improvements in the therapy of AML have been made. Collecting specimens from the blood and bone marrow will increase understanding of the effect of Dipeptidyl Peptidase-4 (DPP-4) Inhibitors on human AML-SCP to develop individualized therapies. We also found DPP4 is highly expressed in other hematological malignancies in our mouse model, thus we would like to use human samples to investigate the role of DPP4 in hematological malignancy development and the mechanism underlying, especially to deeply understand the role of DDP4 in leukemia.


Description:

Specific targets and novel strategies to eliminate AML stem cells are required for AML treatment. Collecting specimens from the blood and bone marrow will increase understanding of the effect of DPP4 inhibitors on human AML-SCP to develop individualized therapies. We will test the effect of DPP4 inhibitors on human AML-SCP in vitro and in vivo and whether the addition of DPP4 inhibitors can prevent AML relapse once the disease is in the remission stage. Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. CML is a steadily developing blood and bone marrow disease that has three stages: chronic, accelerated, and blastic. If it reaches the blastic process, it is known as acute leukemia, which is the same as AML. While the mechanisms of BCR/ABL1-induced transformation are well understood, little is known about the effector molecules that contribute to leukemic SC (LSC) malignant expansion and extramedullary spread in CML. Furthermore, DPP4 is not only highly expressed in leukemia samples, but also specifically expressed in some of the other hematological malignancies, such as AML, CML, ALL, CLL, Lymphomas, or Myelomas, and may work as a stem cell marker as well. At this point, we would like to use human blood samples to investigate the role of DPP4 in hematological malignancy to deeply understand the role of DPP4 in leukemia.


Recruitment information / eligibility

Status Recruiting
Enrollment 50
Est. completion date March 20, 2026
Est. primary completion date March 20, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - All hematological malignancy patients. - Must be 18 years old. Exclusion Criteria: - Participants with impaired decision-making capacities; - Pregnant women or fetuses; - Children (under 18 in Missouri, also dependent on State law); - Non-viable neonates or neonates of uncertain viability (neonates=newborns); - Non-English-speaking subjects; - Prisoners.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Study sample collection
Peripheral blood draws and bone marrow aspiration will be done during clinic visit and hospital stay.

Locations

Country Name City State
United States University of Missouri Columbia Missouri

Sponsors (1)

Lead Sponsor Collaborator
University of Missouri-Columbia

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary DPP4 inhibitors measured in blood samples will be correlated with patient survival data. DPP4 inhibitors measured in blood samples will be used in vitro and in vivo a pre-clinical model. 5 years
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