CAR-T Cellular Therapy for B Cell Malignancies Involved in CNS

Status Recruiting

Clinical Trial Summary

This is a single arm, open-label, single-center study. This study is indicated for relapsed or refractory CD19+ B-line hematological malignancy involved in CNS. 20 patients were enrolled. Primary objective is to explore the safety. The secondary objective is to explore the efficacy.

Clinical Trial Description

This is a single arm, open-label, single-center study. This study is indicated for relapsed or refractory CD19+ B-line hematological malignancy involved in CNS. All together 20 patients were enrolled. Primary objective is to explore the safety including the complication of cytokine release syndrome, CRES, pancytopenia and infection. The secondary objective is to explore the efficacy. We will also detect CAR-T cell expansion dynamics in blood and cerebral fluid and compare the difference. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04287309
Study type	Observational
Source	Zhejiang University
Contact	He Huang, PhD
Phone	13605714822
Email	huanghe@zju.edu.cn
Status	Recruiting
Phase
Start date	February 28, 2020
Completion date	February 28, 2023

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