Hematological Disorder in Patients With Angiodysplasia

Hematological Disease Clinical Trial

Official title:

Hematological Disorder in Patients With Angiodysplasia

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06050798
• Other study ID #: Angiodysplasia
• Status: Not yet recruiting
• Start date: June 1, 2024
• Est. completion date: October 1, 2026

Study information

• Verified date: April 2024
• Source: Assiut University
• Contact: Lydia Mamdouh Sadek
• Phone: 01098293921
• Email: lydia.mamdouh97[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study aim will be to assess the association between GIT angiodysplasia with any hematological disorders such as any specific coagulation disorders or anemia.

Description:

Angiodysplasia is a vascular GI tract abnormality tortous thin walled blood vessels seen in mucosa and submucosa highly prone to rupture resulting in GIT bleeding and hematological disorders ,Impaired coagulation profile and anemia are main changes in angiodysplasia . (An overview of angiodysplasia: management and patient prospects,Grainne Holleran et al. Expert Rev Gastroenterol Hepatol. 2018 Sep.) Gastrointestinal angiodysplasia is a major cause of recurrent bleeding. Haemostatic abnormalities have been implicated in the haemorrhage from these common vascular lesions but their precise contribution remains to be established. (Gastrointestinal angiodysplasiaG Dodda et al. J Assoc Acad Minor Phys. 1997) Angiodyplasia and aortic stenosis are both conditions that are highly prevalent in elderly people and can often co-exist. Recent studies suggest that this association is related to subtle alterations in plasma coagulation factors . The von Willebrand factor is the strongest link between aortic stenosis and bleeding associated with gastrointestinal angiodysplasia. With an aging population, the disease burden of aortic stenosis and its association with angiodysplasia of the bowel makes this an incredibly under-diagnosed yet important condition. This association when dealing with elderly patients presenting either with unexplained anemia, gastrointestinal bleeding or with aortic stenosis should be considered. A high index of suspicion and appropriate diagnostic techniques followed by appropriate and prompt treatment could be life-saving. (Heyde Syndrome Complicated by Essential Thrombocythemia: A Case Report) Chronic hematologic diseases increase the fragility of blood cell components, leading to the progressive destruction of blood cells at the site of aortic stenosis . In this process, further destruction of large multimers of von Willebrand factor may lead to coagulation disorders and gastrointestinal bleeding, such as Heyde syndrome.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 55
• Est. completion date: October 1, 2026
• Est. primary completion date: September 1, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults (above 18 years) and elderly

• Both genders

• Admitted to GIT Unit with manifestations of GIT angiodysplasia diagnosed by upper endoscopy and Colonoscopy.

• bleeding git symptoms

Exclusion Criteria:

• other causes ofGIT bleeding

• bleeding git ulcers

• hematological disorder causing bleeding tendency ex hemophilia

Related Conditions & MeSH terms

• Angiodysplasia
• Hematologic Diseases
• Hematological Disease

Intervention

Diagnostic Test:
• Von willebrand antigen
Von willebrand antigen change and hematological disorder in patients with angiodysplasia

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Selvam S, James P. Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science. Semin Thromb Hemost. 2017 Sep;43(6):572-580. doi: 10.1055/s-0037-1599145. Epub 2017 May 5. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hematological disorder in patients with angiodysplasia	Von willebrand antigen change and anemia and impaired coagulation profile in angiodysplasia	Baseline