Hematological Disease Clinical Trial
Official title:
A Hospital-based Cohort Study in German Hematological / Oncological Wards to Assess the Effect of Contact Isolation on Nosocomial Colonization With ESBL-producing Escherichia Coli (CONTAIN Study)
This study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli (ESBL-EC) and the rate of colonization and infection. On the basis of this study, it will be possible to re-evaluate the need for contact isolation for patients colonized or infected with ESBL-EC.
The study aims to evaluate the impact of contact isolation on the rate of hospital-acquired
transmissions of ESBL-producing Escherichia coli and the rate of colonization and infection.
Hematological and oncological wards in hospitals with a non-outbreak setting for ESBL-EC and
adhering to at least the following standard of care are eligible for study participation:
- Fecal screening for the presence of ESBL-EC of all patients within 72 hours of each
admission by use of a rectal swab or stool sample
- Follow-up fecal screening once a week and within 72 hours of discharge
- Implementation of clinical standards aimed at ESBL-EC decolonization is not allowed on
wards participating in this study, including in the context of clinical studies.
Sites will be grouped according to their approach regarding contact isolation (see group
description).
As a control for external factors a hand hygiene program, including training and adherence
assessments, will be implemented.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02660281 -
URMC Related Haplo-identical Donor BMT
|
Phase 1 | |
| Completed |
NCT03004261 -
CMV-CTL for the Treatment of CMV Infection After HSCT
|
Phase 4 | |
| Recruiting |
NCT01684189 -
Registry of Febrile Neutropenia and Invasive Fungal Infections
|
N/A | |
| Completed |
NCT02447237 -
Randomized Trial:the Effect of Liquid Food on the Intake of Energy and Protein in Malignant Hematologic Patients
|
N/A | |
| Not yet recruiting |
NCT06143098 -
Some Hematological Profile in Children With Chronic Kidney Disease
|
||
| Recruiting |
NCT04976205 -
AI Algorithms to Automate the TMI by VMAT Optimization Using WB-CT/MRI and Synthetic WB-CT - The AuToMI Project
|
N/A | |
| Active, not recruiting |
NCT02158858 -
A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06050798 -
Hematological Disorder in Patients With Angiodysplasia
|
||
| Recruiting |
NCT05727917 -
Hetrombopag for the Enhancement of Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation
|
N/A | |
| Completed |
NCT03355742 -
XIENCE 28 Global Study
|
N/A | |
| Recruiting |
NCT00883961 -
Exercise Following Autologous Peripheral Blood Stem Cell Transplantation
|
Phase 3 | |
| Completed |
NCT00820508 -
Safety and Tolerability of CHR-2845 to Treat Haematological Diseases or Lymphoid Malignancies
|
Phase 1 | |
| Terminated |
NCT01359254 -
Cord Blood Transplantation for Patients With Cancer
|
Phase 2 |