ATG Plus Low-dose PT-Cy for GVHD Prevention

Status Recruiting

Clinical Trial Summary

During the past decades, the wider application of easily available haploidentical donor hematopoietic cell transplant (haplo-HCT) has been made possible through the T cell-replete (TCR) regimens including T cell regulation with anti-thymocyte globulin (ATG)/granulocyte colony-stimulating factor (GCSF) and post-transplant cyclophosphamide (PTCy). To achieve decreased non-relapse mortality (NRM) and improved long-term outcomes in haploidentical transplant, the joint use of ATG and PTCy might effectively reduce graft versus host disease (GVHD) and mortality associated with severe forms of GVHD. Recently, investigators established a regimen using low-dose PTCy in conjunction with standard-dose ATG in order to lower the risk of GVHD without compromising engraftment and disease relapse.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06108739
Study type	Interventional
Source	Peking University People's Hospital
Contact	Yu Wang, M.D.
Phone	86-13552647384
Email	ywyw3172@sina.com
Status	Recruiting
Phase	Phase 3
Start date	November 1, 2023
Completion date	June 30, 2025

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