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A Phase II Single-arm Study of Total Body Irradiation With Linac Based VMAT and IGRT

Hematologic Malignancy Clinical Trial

Official title:
A Phase II Single-Arm Study of Total Body Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) and Image Guided Radiation Therapy (IGRT)

Clinical Trial Summary

Single institution study of safety of linac based VMAT TBI for myeloablative treatment in hematologic malignancies.

Clinical Trial Description

Total Body Irradiation (TBI) continues to play an important role in myeloablative and non-myeloablative conditioning regimens for Allogeneic Stem Cell Transplant (ASCT). When TBI is used as part of a myeloablative regimen, it is combined with chemotherapy to eradicate malignant cells, as well as to immunosuppress the host to prevent rejection of donor hematopoietic progenitor cells (HPC). This study is a single-institution study to assess the safety of linac based VMAT TBI for myeablative sreatment in hematologic malignancies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04509765
Study type Interventional
Source NYU Langone Health
Contact
Status Active, not recruiting
Phase N/A
Start date September 22, 2020
Completion date September 9, 2024
View Details
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