Clinical Trials Logo
  1. Home
  2. Hemangioma
  3. NCT01074437

Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)

Hemangioma Clinical Trial

Official title:
A Phase II, Randomized, Double-Blind Comparison of Corticosteroid and Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)

Clinical Trial Summary

This is a prospective randomized, double-blind study to compare the clinical efficacy of infantile hemangioma treatment using propranolol with corticosteroids as compared to therapy with corticosteroids and placebo. We hypothesize that a two-month treatment period with propranolol plus corticosteroids is more effective at reducing infantile hemangioma size and vascularity when compared to corticosteroids used without propranolol for the same time period.

Clinical Trial Description

Infantile hemangiomas (IH) are the most common head and neck pediatric tumors. Presence of these tumors can lead to complications of vision and airway compromise, bleeding and disfigurement. Medical treatment of these lesions has traditionally been focused on stopping new blood vessel growth with corticosteroids. Recent reports and our own experience have demonstrated that significant reduction in IH size and vascularity can also occur through the use of propranolol. Our initial experience with propranolol has demonstrated significant efficacy with fewer side effects than corticosteroids. Despite this experience, the standard of care for initial IH medical therapy remains corticosteroids.

This Trial is a direct comparison of traditional IH therapy with corticosteroids to newer therapy with propranolol and corticosteroids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01074437
Study type Interventional
Source Seattle Children's Hospital
Contact
Status Terminated
Phase Phase 2
Start date February 2010
Completion date February 2013
View Details
See also
  Status Clinical Trial Phase
Completed NCT01685398 - Topical Timolol for Superficial Infantile Hemangioma Phase 3
Withdrawn NCT00974129 - A Study of CCCTC-binding Factor (CTCF) in Infantile Hemangiomas N/A
Completed NCT00374335 - Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas N/A
Recruiting NCT03331744 - Clinical Characteristics of Infantile Hemangioma
Completed NCT02342275 - Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Phase 3
Completed NCT00433940 - Immune Suppression Of Infants Treated With Steroids N/A
Completed NCT04065217 - The Effectiveness of Diode Laser 980-nm in Iraqi Face Hemangioma: a Randomized Within Patients Trial N/A
Terminated NCT01743885 - Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Phase 3
Terminated NCT00555464 - Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas Phase 2
Completed NCT00394888 - Hemangioma Associated With High Rates of Morbidity N/A
Completed NCT05327309 - Role of Propranolol as Compared to Bleomycin in Management of Hemangioma N/A
Completed NCT02145884 - Topical Timolol Gel for the Treatment of Infantile Hemangiomas Phase 2
Completed NCT04077515 - Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma Phase 4
Completed NCT02731287 - Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Phase 2
Recruiting NCT01147601 - Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas Phase 0
Completed NCT01908972 - The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma Phase 4
Completed NCT00540566 - Optical Biopsy of Human Skin in Conjunction With Laser Treatment
Completed NCT00001417 - Direct Injection of Alcohol for the Treatment of Spinal Tumors N/A
Completed NCT00004436 - Randomized Study of Hormonal Regulation of Infantile Hemangioma N/A
Recruiting NCT02496013 - Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB Phase 1