Infantile Hemangioma With Minimal or Arrested Growth : Epidemiology, Clinical Characteristics and Evolution

Hemangioma, Capillary Clinical Trial

Official title:

Comparing Epidemiological and Clinical Characteristics of Infantile Hemangioma With Minimal or Arrested Growth (IH-MAG) and Classic Infantile Hemangioma : a Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05080868
• Other study ID #: 2019PI221
• Status: Completed
• Start date: March 23, 2021
• Est. completion date: August 15, 2021

Study information

• Verified date: October 2021
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Infantile hemangioma (IH) is the most common vascular tumor of infancy, characterized by its clinical history. Absent at birth or present under the form of a premonitory mark, they display a rapid proliferative phase starting in the first weeks of life. Then, after a plateau phase, they slowly involute. However, a subtype of IH named "abortive", "minimal or arrested growth", "reticular" or "telangiectatic" hemangioma differs from typical IH because it doesn't have a proliferative component, or only a minimal one. This subtype of hemangioma has been recently described and data are lacking regarding its proportion among infantile hemangioma and its differences with "classic" infantile hemangioma. The aim of this study is to estimate the proportion of abortive hemangioma among infantile hemangioma. Also, the investigators aim to compare the clinical characteristics of "classic" infantile hemangiomas and abortive hemangiomas. Lastly, investigators wished to study the evolution of abortive hemangioma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 224
• Est. completion date: August 15, 2021
• Est. primary completion date: May 30, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• Children between 0 and 18 years old

• Followed in the dermatology department of CHRU de Nancy between January 2014 and December 2020

• Presenting with one or more infantile hemangioma

Exclusion Criteria:

• Those whoes guardian does not want his data to be collected in this study

Related Conditions & MeSH terms

• Hemangioma
• Hemangioma, Capillary
• Port-Wine Stain

Locations

Country	Name	City	State
France	CHRU de Nancy	Nancy	Grand-Est

Sponsors (1)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proportion of abortive hemangioma among infantile hemangioma	Proportion of abortive hemangioma among infantile hemangioma	baseline
Secondary	To compare the epidemiological characteristics between infantile hemangioma and abortive hemangioma : sex	Compare sex predominance between infantile hemangioma and abortive hemangioma	baseline
Secondary	To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : prematurity	Compare prematurity rates between infantile hemangiomas and abortive hemangiomas	baseline
Secondary	To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : birthweight	Compare birthweight between infantile hemangiomas and abortive hemangiomas	baseline
Secondary	To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : localization	Compare localization between infantile hemangiomas and abortive hemangiomas	baseline
Secondary	To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : treatment	le hemangiomas and abortive hemangiomaCompare treatment between infanti	baseline
Secondary	To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : complications	Compare complications between infantile hemangiomas and abortive hemangioma	baseline
Secondary	To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : size	Compare size (focal, extended or segmental) between infantile hemangiomas and abortive hemangioma	baseline
Secondary	To study the evolution of abortive hemangioma : erythematous macule	Evaluation of the fading of erythematous macule between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years
Secondary	To study the evolution of abortive hemangioma : papules of proliferation	Evaluation of the regression of the papules of proliferation between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years
Secondary	To study the evolution of abortive hemangioma : telangiectasias	Evaluation of the fading of telangiectasias between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years
Secondary	To study the evolution of abortive hemangioma : halo of vasoconstriction	Evaluation of the fading of the vasoconstricted halo between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years
Secondary	To study the evolution of abortive hemangioma : areas of vasoconstriction	Evaluation of the fading of vasoconstricted areas between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years
Secondary	To study the evolution of abortive hemangioma : dilated veins	Evaluation of the fading of dilated veins between the stage of maximal proliferation and the last follow-up	through study completion, an average of 4 years