Helicobacter Pylori Clinical Trial
Official title:
A Comparison of High-dose Dual Therapy and Half-dose Clarithromycin-containing Bismuth Quadruple Therapy for H.P Eradication in Elderly Patients
The purpose of this study is to assess and compare the effectiveness and safety of high-dose dual therapy and half-dose clarithromycin-containing bismuth quadruple therapy in elderly patients for eradicating H.pylori.
Helicobacter pylori plays an important role in many diseases such as peptic ulcer disease and
MALT lymphomas. And the prevalence of H. pylori remains high in developing
countries,including China.
Clarithromycin-containing bismuth quadruple therapy has been recommended as the first-line
therapy for H pylori infection in China. However, its expensive cost and high
antibiotic‐related adverse reactions are always haunting us. In 2018,a research from NanFang
hospital(China)revealed that 250mg clarithromycin is as effective as 500mg clarithromycin,at
the same time,causes less adverse reactions. On the othe hand,previous studies reported a new
regimen called large dose dual therapy(generally contains a PPI and amoxicillin),while some
of them have achieved very good results,especially in Taiwan.
However, specific data on anti-H.pylori treatments in elderly people are very lacking.So,we
aim to assess and compare the effectiveness and tolerability of high-dose dual therapy and
half-dose clarithromycin-containing bismuth quadruple therapy in elderly patients.Considering
the difference of drug metabolism between eldery and young people,a satisfactory result may
be obtained.
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