Helicobacter Pylori Infection Clinical Trial
Official title:
Double-blind, Placebo-controlled, Randomized Study for Assesment of the Efficiency and Safety Quadruple Therapy for Helicobacter Pylori Infection With or Without the Addition of Saccharomyces Boulardi Probiotic
This study assesses the effect of quadruple therapy for H. pylori, with the addition of probiotics Saccharomyces boulardii. In addition, he assesses whether this combination reduces the frequency of adverse effects of eradication therapy, and whether it affects the compliance.
Standard triple therapy for H. pylori infection proved to be insufficiently effective,
primarily due to antibiotics resistance.Therefore, the latest Maastricht consensus suggests
using bismuth-quadruple or non-bismuth-quadruple therapy, in regions with high clarithromycin
resistance. The addition of probiotics with eradication therapy has never become a standard
treatment. However, the Maastricht consensus suggest that the addition of probiotics could
increase the effectiveness of quadruple therapy.
The study was designed as a prospective, double-blind, randomized, case-control intervention
study.
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