Helicobacter Pylori Infection Clinical Trial
Official title:
Efficacy and Safety of a 14-day Modified Sequential Therapy for Refractory Helicobacter Pylori Infection: a Pilot Study
The purpose of this study is to assess efficacy of a 14-day sequential therapy for the rescue treatment of refractory Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
Half of the world's population is infected with Helicobacter pylori. Strong evidence supports
that H.pylori eradication is an effective approach to reduce the risk of developing gastric
cancer. However, eradication rates of first-line therapy decreased over years due to the
rapidly emerging antibiotic resistance of H. pylori worldwide. An ideal rescue therapeutic
regimen to cure refractory H.pylori infection is currently warranted.
Traditional sequential therapy failed to achieve an ideal eradication rates (over>95%) as a
third line treatment in the region with high antibiotic resistance. The investigator's study
aims to evaluate the efficacy 14-day modified sequential therapy in the patients with two or
more treatment failure, and whether the adverse effects of this new modified sequential
therapy are tolerable.
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