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Heart Valve Prosthesis clinical trials

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NCT ID: NCT01042067 Suspended - Atrial Fibrillation Clinical Trials

Safer Warfarin Treatment

CYKOWAR
Start date: January 2010
Phase: N/A
Study type: Observational

The study is a national multicenter prospective observational study, including 200 patients. The main purpose of this study is to explore in more detail the influence of genetic variability (CYP enzymes and vitamin K dependent proteins) and dietary vitamin K status on warfarin dosing, clinical effect and adverse events with emphasis on the initial phase of treatment. The hypothesis is that genetic variability concerning CYP enzymes and vitamin K dependent proteins predict dosing and adverse events during warfarin treatment. The main aim is to individualize warfarin therapy and establish a treatment algorithm based on genotype and dietary vitamin K status to make the anticoagulation therapy with warfarin more secure.