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Clinical Trial Summary

1. Title: Clinical study of the relationship between Pharmacogenomics and warfarin dose in Chinese patients

2. Drug: Warfarin

3. Design: To value the accuracy of warfarin Pharmacogenomics algorithm by the algorithm calculated dose and actual dose in the Chinese patients.

4. Hypothesis:Pharmacogenomic algorithm guided dose can help to predict warfarin dose in Chinese patients.


Clinical Trial Description

- For the patients who need to use warfarin, detect the "Vitamin K epoxide reductase complex subunit 1 (VKORC1),cytochrome p450 2C9 (CYP2C9), and cytochrome p450 4F2 (CYP4F2) genotype.

- Record the demographic information: gender, age, height, and weight.

- Record drug combination, complications, and international normalized ratio (INR), liver function and kidney function or other biochemical test results.

- Put genotypes, demographic information and other clinical information into the algorithm to calculate warfarin dose for the patients, and compared with the actual dose. ;


Study Design

Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01855737
Study type Observational
Source Chinese Academy of Medical Sciences, Fuwai Hospital
Contact Hong Liu, MS
Phone +86 10 88398547
Email winterliucn@gmail.com
Status Recruiting
Phase Phase 4
Start date June 2013
Completion date January 2014

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