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Daratumumab-SC for Highly Sensitized Patients Awaiting Heart Transplantation

Heart Transplant Failure and Rejection Clinical Trial

Official title:
A Phase 1 Study of Daratumumab-SC for Reduction of Circulating Antibodies in Patients With High Allosensitization Awaiting Heart Transplantation

Clinical Trial Summary

The purpose of this study is to test whether Daratumumab-SC, a drug that eliminates antibody-producing plasma cells, can effectively lower the level of preformed antibodies in patients awaiting heart transplantation. These preformed antibodies limit the number of donor hearts that are compatible for the patients. If Daratumumab-SC can effectively remove preformed, donor-specific antibodies, then highly allosensitized patients will have more compatible hearts available to them, potentially decreasing transplant waitlist time and reducing mortality.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04610320
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 1
Start date July 1, 2021
Completion date January 26, 2024
View Details
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