Heart Failure Clinical Trial
Official title:
Serum Uric Acid Levels and Initial Presentation of Cardiovascular Diseases: a CALIBER Study
Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial results. Estimation of this association may help to predict cardiovascular outcomes and may guide new treatment strategies. The hypothesis is that increased serum uric acid level is associated with a range of cardiovascular diseases.
Smaller observational studies suggested that increased serum uric acid level is associated
with increased incidence of several cardiovascular diseases. Associations with specific
initial presentations of cardiovascular diseases have not been studied in large cohort from
the general population, but may be of interest for use in risk prediction or to guide
therapeutic strategies.
The aim of this study is to estimate associations between serum uric acid level and initial
presentation of a range of cardiovascular diseases.
The study will use data from the CALIBER dataset of clinically collected electronic health
record data from England. Patients enter the study when they have a blood urate measurement
recorded in the dataset, and they are followed up until they experience one of the
cardiovascular endpoints, death or transfer out of the participating primary care practice.
This study is part of the CALIBER (Clinical disease research using linked bespoke studies and
electronic records) programme funded from the National Institute for Health Research (NIHR)
and Wellcome Trust. The central theme of the CALIBER research is linkage of the Inpatient
Hospital Episode Statistics (HES) with primary care (Clinical Practice Research Datalink) and
other resources. The overarching aim of CALIBER is to better understand the aetiology and
prognosis of specific coronary phenotypes across a range of causal domains, particularly
where electronic records provide a contribution beyond traditional studies. CALIBER has
received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009
CALIBER dataset).
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