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Clinical Trial Summary

Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well documented. However, few studies have investigated associations with onset of disease. The initial manifestation of CVD, for example an episode of unstable angina, is important because it influences the prognosis, the quality of life and the management of disease. Furthermore, the extent to which social deprivation, alcohol consumption or atrial fibrillation affects presentation of CVD is poorly understood and deserves further consideration.

Most previous studies have considered CVD as a single entity. However, differences in aetiology between coronary phenotypes suggest that risk factors may not be shared across specific coronary phenotypes and their relative importance is likely to differ for each phenotype. Gaining knowledge of these differences could provide insights into the pathophysiology of specific forms of CVD and could eventually lead to modification of recommendations for patient management and disease prevention.

We propose to use the linkage of the national registry of coronary events to general practice records in the Clinical Practice Research Database (CPRD), to investigate whether demographic, behavioral, and clinico-metabolic risk factors differentially influence the onset of specific types of CVD.


Clinical Trial Description

n/a


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms

  • Abdominal Aortic Aneurysm
  • Acute Myocardial Infarction
  • Aneurysm
  • Angina Pectoris
  • Angina, Stable
  • Angina, Unstable
  • Aortic Aneurysm
  • Aortic Aneurysm, Abdominal
  • Cardiac Arrest
  • Cardiovascular Diseases
  • Cerebrovascular Accident
  • Chronic Stable Angina
  • Death
  • Death, Sudden
  • Heart Arrest
  • Heart Diseases
  • Heart Failure
  • Hemorrhage
  • Infarction
  • Ischemia
  • Ischemic Attack, Transient
  • Ischemic Stroke
  • Myocardial Infarction
  • Peripheral Arterial Disease
  • Peripheral Vascular Diseases
  • Stroke
  • Subarachnoid Hemorrhage
  • Sudden Coronary Death
  • Sudden Death
  • Transient Ischemic Attack
  • Unstable Angina
  • Ventricular Arrhythmia

NCT number NCT01804439
Study type Observational [Patient Registry]
Source University College, London
Contact
Status Completed
Phase N/A
Start date January 1997
Completion date March 2010

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