Heart Failure Clinical Trial
Official title:
Cardiovascular Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes: a CALIBER Proposal Using Linked GPRD-MINAP-HES Data
Cardiovascular disease (CVD) is an important public health problem that affects millions of
people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or
hypertension, and prevalent CVD are well documented. However, few studies have investigated
associations with onset of disease. The initial manifestation of CVD, for example an episode
of unstable angina, is important because it influences the prognosis, the quality of life
and the management of disease. Furthermore, the extent to which social deprivation, alcohol
consumption or atrial fibrillation affects presentation of CVD is poorly understood and
deserves further consideration.
Most previous studies have considered CVD as a single entity. However, differences in
aetiology between coronary phenotypes suggest that risk factors may not be shared across
specific coronary phenotypes and their relative importance is likely to differ for each
phenotype. Gaining knowledge of these differences could provide insights into the
pathophysiology of specific forms of CVD and could eventually lead to modification of
recommendations for patient management and disease prevention.
We propose to use the linkage of the national registry of coronary events to general
practice records in the Clinical Practice Research Database (CPRD), to investigate whether
demographic, behavioral, and clinico-metabolic risk factors differentially influence the
onset of specific types of CVD.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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