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Clinical Trial Summary

The objective is to evaluate the efficacy and safety on the tolvaptan for increasing serum Na levels in patients with worsening heart failure and hyponatremia.


Clinical Trial Description

This is a phase 4, multicenter, randomized, double-blind, placebo-controlled, parallel-group interventional study comparing tolvaptan (15 to 60 mg) to placebo in adult patients hospitalized (or admission to emergency room) due to worsening of heart failure and dilutional hyponatremia. All patients will be on standard therapy for heart failure. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02352285
Study type Interventional
Source Korea Otsuka Pharmaceutical Co., Ltd.
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Status Terminated
Phase Phase 4
Start date December 2012
Completion date January 2017